The Efficacy and Safety of Lanthanum Carbonate on Chronic Kidney Disease Mineral and Bone Disorder in Patients with Dialysis:A Systematic Review

Author's response to reviews Title: The Efficacy and Safety of Lanthanum Carbonate on Chronic Kidney Disease Mineral and Bone Disorder in Dialysis Patients : A Systematic Review Authors:

Efficacy and safety of lanthanum carbonate on chronic kidney disease–mineral and bone disorder in dialysis patients: a systematic review

BACKGROUND Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a common complication in CKD patients, particularly in those with end-stage renal disease that requires dialysis. Lanthanum carbonate (LC) is a potent, non-aluminum, non-calcium phosphate binder. This systematic review evaluates the efficacy and safety of LC in CKD-MBD treatment for maintenance-dialysis patients. METHODS...

Non-calcium-containing phosphate binders: comparing efficacy, safety, and other clinical effects.

Phosphate-binder therapy for hyperphosphataemia is key to the treatment of patients with chronic kidney disease (CKD)-mineral and bone disorder (MBD). Calcium-free phosphate binders are increasingly favoured since calcium-based agents potentially cause harmful calcium overload and vascular calcification that confound the benefits of reducing serum phosphorus. Several calcium-free phosphate bind...

Effects of different phosphate lowering strategies in patients with CKD on laboratory outcomes: A systematic review and NMA

BACKGROUND Chronic kidney disease-mineral and bone disorder (CKD-MBD), a complication of chronic kidney disease, has been linked to reduced quality and length of life. High serum phosphate levels that result from CKD-MBD require phosphate-lowering agents, also known as phosphate binders. The objective of this systematic review is to compare the effects of available phosphate binders on laborato...

Long-term treatment with lanthanum carbonate reduces mineral and bone abnormalities in rats with chronic renal failure

BACKGROUND Lanthanum carbonate (FOSRENOL(®), Shire Pharmaceuticals) is an effective non-calcium, non-resin phosphate binder for the treatment of hyperphosphataemia in patients with chronic kidney disease (CKD). In this study, we used a rat model of chronic renal failure (CRF) to examine the long-term effects of controlling serum phosphorus with lanthanum carbonate treatment on the biochemical a...